Contains c.55 items, of Dr. Alfred Leyburn and the Leyburn family of Lexington, Va., including 22 letters between Leyburn and his wife, Ann Eliza, 1835-36; patents of Edward J. Leyburn.

This folder contains the history of the Caruthers family, including the granting of a slave to Rebecca Caruthers, the wife of Samuel Caruthers, and the granting of slaves to the daughters and granddaughters of Captain John Caruthers.

Includes folders on Campbell/Houston family, Edmund D. Campbell, Harry D. Campbell, John Lyle Campbell, John Poage Campbell, Leslie Lyle Campbell, Robert F. Campbell, Robert K. Campbell, W. A. Campbell, William S. Campbell, Horace Caruthers, John A. Champe, Chapin family, Chittum, John Coalter, Christopher Columbus, Robert Page Cooke, Mary Beard Copper, Rev. John Craig, Jane Todd Crawford, James S. A. Crawford, Crozet family, Ernest Cummings, and Cunningham family.

William Caruthers (and his wife Louisa) writes to Ann Eliza about his life and medical practice in Kanawha, Va.

William writes of Mrs. Calhoun's activities, his medical work, prices of goods, and business opportunities.

This file consist of six separate vouchers from 1798, signed by William Carruthers and Eliza Paxton.